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Assignment of resonances for ‘acute‐phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma
Author(s) -
Bell J.D.,
Brown J.C.C.,
Nicholson J.K.,
Sadler P.J.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80168-0
Subject(s) - glycoprotein , chemistry , spectral line , nuclear magnetic resonance , phase (matter) , human blood , human plasma , biochemistry , chromatography , physics , biology , organic chemistry , astronomy , physiology
Broad resonances at 2.04 and 2.08 ppm in 500 MHz Hahn spin‐echo 1 H NMR spectra of human blood plasma are assigned to the N ‐acetyl groups of mobile carbohydrate side‐chains (largely N ‐acetylglucosamine and N ‐acetylneuraminic acid) of glycoproteins such as α 1 ,‐acid glycoprotein. Their intensities in spin‐echo spectra correlate with clinical conditions in which an elevation of the level of ‘acute‐phase’ glycoproteins is expected, and so may be of value in the study of certain diseases.