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Increased synthesis of poly(ADP‐ribose) in isolated liver nuclei from autoimmune NZB/NZW mice
Author(s) -
Haug Brenda L.,
Sibley John T.,
Lee Jeremy S.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80156-4
Subject(s) - poly adp ribose polymerase , ribose , autoimmunity , nad+ kinase , enzyme , polymerase , chemistry , biochemistry , metabolism , microbiology and biotechnology , biology , immunology , antibody
The synthesis and degradation of poly(ADP‐ribose) were investigated in isolated liver nuclei from autoimmune NZB/W mice and four strains of normal mice. Compared to normal mice the maximum levels of incorporation of P[ 3 H]NAD into poly(ADP‐ribose) were increased about 2‐fold in the autoimmune mice. The kinetics of incorporation suggested that this change was due to an increase in the activity of the polymerase rather than a decrease in the level of degradative enzymes. Thus there may be a connection between autoimmunity and poly(ADP‐ribose) metabolism.