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Evidence for a signal peptide at the amino‐terminal end of human mitochondrial aldehyde dehydrogenase
Author(s) -
Braun Thomas,
Bober Eva,
Singh Surjit,
Agarwal Dharam P.,
Goedde H.Werner
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80152-7
Subject(s) - aldehyde dehydrogenase , complementary dna , signal peptide , mitochondrion , cdna library , biochemistry , peptide sequence , aldh2 , microbiology and biotechnology , biology , chemistry , enzyme , gene
A full‐length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH 1) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino‐terminal end of ALDH I and other known targeting sequences responsible for protein uptake into the mitochondria.