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cAMP reduces the affinity of Ca 2+ ‐triggered secretion in platelets
Author(s) -
Collazos José Maria,
Sanchez Ana
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80138-2
Subject(s) - intracellular , secretion , prostacyclin , platelet , ionophore , chemistry , biophysics , microbiology and biotechnology , biochemistry , medicine , biology , membrane
Prostacyclin and other related compounds known to increase intracellular cAMP levels inhibit platelet responses. The mechanisms involved are only partially known, especially those concerning the complex relations between Ca 2+ and cAMP as opposite intracellular mediators. Here, we have investigated aggregation and secretion in quin2‐loaded platelets under conditions in which Ca 2+ and cAMP are the only intracellular mediators. Our results show that cAMP inhibits aggregation and secretion in ionophore‐treated cell without modifying their intracellular Ca 2+ levels. This result suggests that the inhibition takes place on some intracellular target for Ca 2+ .