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Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells
Author(s) -
Norton J.D.,
Leber B.,
Yaxley J.C.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80126-6
Subject(s) - chronic lymphocytic leukemia , gene expression , gene , biology , microbiology and biotechnology , immunology , cancer research , genetics , leukemia
Chronic lymphocytic leukaemia (CLL) cells may be induced to undergo plasmacytoid differentiation in vitro in response to 12‐ O ‐tetradecanoyl phorbol acetate (TPA). We show here that plasmacytoid differentiation and the accompanying accumulation of Cμ immunoglobulin mRNA are preceded by a rapid transient increase in the expression of the proto‐oncogenes, c‐myc and c‐fos . In terminally differentiated cells the level of c‐fos mRNA returned to the original basal level whilst c‐myc expression remained appreciably higher than in undifferentiated CLL cells. These data support a possible role for c‐fos and c‐myc in the programmed chain of events that occur during terminal differentiation of B‐lymphocytes.