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Temporal relationships in the effects of protein‐free diet on the activities of rat liver branched‐chain ketoacid dehydrogenase complex and kinase
Author(s) -
Beggs M.,
Patel H.,
Espinal J.,
Randle P.J.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80104-7
Subject(s) - casein , activator (genetics) , medicine , endocrinology , dehydrogenase , casein kinase 2 , enzyme , pi , chemistry , biochemistry , kinase , protein kinase a , biology , receptor , mitogen activated protein kinase kinase
Feeding rats 0% casein diet decreased liver activities of branched‐chain ketoacid dehydrogenase complex (active form) and of activator protein (complete within 4 days), and increased activity of branched‐chain ketoacid dehydrogenase kinase (complete within 9–10 days). Refeeding normal diet to rats fed 0% casein diet for 10 days resulted in a rapid and partial (approx. 50%) reversal of the above effects within 24 h; complete reversal required 20–30 days of refeeding.