Premium
Bromoacetylalprenololmenthane binding to β‐receptors modulates the rate of hormone‐induced internalization but not desensitization in S49 cells
Author(s) -
Box Rainer-Joachim,
Staehelin Matthys
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80079-0
Subject(s) - internalization , desensitization (medicine) , receptor , homologous desensitization , microbiology and biotechnology , chemistry , cyclase , endocrinology , biology , medicine , biochemistry
Bromoacetylalprenololmenthane was found to inhibit hormone‐induced β‐adrenergic receptor internalization in a dose‐dependent fashion in S49 lymphoma cells, besides its known ability to bind to β‐receptors irreversibly. This new found property of BAAM + was taken advantage of in studying whether receptor internalization is a necessary step in the desensitization of adenylate cyclase. BAAM‐treated cells showed functional desensitization even when receptor internalization had been blocked substantially by 50–65% This finding suggests that receptor internalization is not directly involved in desensitization.