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Studies on rationales for an expert system approach to the interpretation of protein sequence data Preliminary analysis of the human epidermal growth factor receptor
Author(s) -
Fishleigh Robert V.,
Robson Barry,
Garnier Jean,
Finn Paul W.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80060-1
Subject(s) - sequence (biology) , computational biology , sequence analysis , variety (cybernetics) , biology , protein secondary structure , peptide sequence , bioinformatics , computer science , genetics , biochemistry , artificial intelligence , gene
The molecular modelling of larger proteins benefits from a preliminary analysis of the sequence to identify regions of potential structural and functional importance. In this study the sequence of the epidermal growth factor receptor has been analysed using a variety of established methods and novel procedures developed for the study of weak internal and external homologies and for the use of homologous sequences in the prediction of secondary and super‐secondary structures. The procedures explored here are potentially suitable for incorporation into an expert system for the initial investigation of protein sequence data.