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Adenovirus infection reverses the antiviral state induced by human interferon
Author(s) -
Feduchi Elena,
Carrasco Luis
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80032-7
Subject(s) - reversion , poliovirus , virology , interferon , hela , biology , picornavirus , virus , aphidicolin , lymphoblast , cell culture , rna , gene , genetics , dna polymerase , phenotype
HeLa cells treated with human lymphoblastoid interferon do not synthesize poliovirus proteins. The antiviral state against poliovirus is reversed if cells are previously infected with adenovirus type 5. A late gene product seems to be involved in this reversion, since no effect is observed at early stages of infection or in the presence of aphidicolin.