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Differential effects of cadmium on cytosolic and mitochondrial glutathione levels in the rat heart
Author(s) -
Jamall Ijaz S.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80013-3
Subject(s) - cytosol , glutathione , selenium , cadmium , mitochondrion , medicine , chemistry , endocrinology , biochemistry , biology , enzyme , organic chemistry
In rats fed a low‐selenium diet, cytosolic GSH levels in the heart were significantly elevated when compared to rats fed a selenium‐supplemented diet. Similar results were obtained in cardiac cytosol from rats treated with either parenteral or dietary Cd. Mitochondrial GSH was not affected by cadmium in selenium‐deficient rats, However, significant elevations of mitochondrial GSH were seen in cadmium‐treated rats fed either 0.1 or 0.5 ppm selenium. The alterations in cytosolic GSH levels correlate with reductions in GSH‐Px activity reported earlier [(1987) Toxicol. Appl. Pharmacol. 87, in press]. However, levels of mitochondrial GSH did not correlate with GSH‐Px activity.