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Calcium‐binding proteins in rat skin
Author(s) -
Schelling Claude P.,
Didierjean Liliane,
Rizk Marthe,
Pavlovitch Jana H.,
Takagi Takashi,
Heizmann Claus W.
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80006-6
Subject(s) - parvalbumin , epidermis (zoology) , calcium binding protein , calcium , amino acid , biochemistry , binding protein , peptide sequence , chemistry , biology , anatomy , genetics , gene , organic chemistry
Skin Ca 2+ ‐binding protein (SCaBP) was reported to be distinct from the Ca 2+ ‐binding parvalbumin (PV), however, more recently its amino acid sequence was shown to be identical to PV. We purified a protein ( M r 12 000; p I 4.5) from isolated epidermis (free of other cell layers) of adult rats and whole skin (containing no PV) of newborn rats. This protein is referred to as epidermal protein (EP‐12), distinct from PV in its hydrophobicity, amino acid composition and immunological properties. Previously isolated SCaBP was shown to be a mixture of EP‐12 and PV. The localization and possible functions of EP‐12 and of PV in skin of adult and newborn rat are discussed.