Premium
Release of immunoreactive atrial natriuretic factor from the isolated perfused rat lung
Author(s) -
Gutkowska Jolanta,
Cantin Marc,
Genest Jacques,
Sirois Pierre
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)80005-4
Subject(s) - prohormone , zona glomerulosa , medicine , endocrinology , aldosterone , secretion , forskolin , atrial natriuretic peptide , chemistry , lung , amino acid , peptide hormone , biology , biochemistry , angiotensin ii , hormone , stimulation , blood pressure
The secretion of ANF by the rat lung was demonstrated in the present study. Four forms of immunoreactive ANF were detected in rat lung homogenates, including the 126 amino acid prohormone but only a low molecular mass peptide was released during lung perfusion. The released ANF inhibited forskolin‐stimulated aldosterone secretion from rat zona glomerulosa cell suspensions, and this biological effect was comparable to that of the synthetic C‐terminal part of the prohormone (Arg‐101—Tyr‐126).