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all‐ trans ‐Retinoic acid inhibits the appearance of two phorbol ester‐induced ornithine decarboxylase mRNAs in mouse epidermis
Author(s) -
Kumar S.,
de Vellis J.,
Lowe N.J.,
Weingarten D.P.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81551-4
Subject(s) - retinoic acid , ornithine decarboxylase , messenger rna , epidermis (zoology) , phorbol ester , phorbol , microbiology and biotechnology , chemistry , tretinoin , biochemistry , enzyme , biology , gene , anatomy , protein kinase c
Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12‐ O ‐tetradecanoyl phorbol‐13‐acetate (TPA). This induction occurs in a time‐ and dose‐dependent fashion and appears to be relatively specific as α‐actin mRNA reveals no change with treatment. Both mRNA species are inhibited in a dose‐dependent manner by treating mouse skin with all‐ trans ‐retinoic acid prior to TPA. These results indicate that these two compounds are active at the transcriptional level.