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Identification of granzyme A isolated from cytotoxic T‐lymphocyte‐granules as one of the proteases encoded by CTL‐specific genes
Author(s) -
Masson Daniéle,
Zamai Moreno,
Tschopp Jürg
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81537-x
Subject(s) - granzyme a , ctl* , proteases , cytotoxic t cell , granzyme , gene , granzyme b , identification (biology) , biology , chemistry , microbiology and biotechnology , biochemistry , perforin , enzyme , in vitro , botany
A serine esterase called granzyme A, which is specifically expressed in cytolytic lymphocytes has been characterized. It is a disulfide‐linked dimer and exhibits a trypsin‐like specificity cleaving best after Arg. N‐terminal sequence analysis revealed that granzyme A is identical to a protease recently predicted from a cloned CTL‐specific gene.