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cDNA sequence of human β‐preprotachykinin, the common precursor to substance P and neurokinin A
Author(s) -
Harmar A.J.,
Armstrong A.,
Pascall J.C.,
Chapman K.,
Rosie R.,
Curtis A.,
Going J.,
Edwards C.R.W.,
Fink G.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81534-4
Subject(s) - neurokinin a , substance p , complementary dna , peptide sequence , neuropeptide , nucleic acid sequence , amino acid , chemistry , microbiology and biotechnology , sequence (biology) , biochemistry , peptide , cdna library , tachykinin receptor 1 , biology , gene , receptor
The nucleotide sequence of cDNA encoding the human substance P precursor, β‐preprotachykinin (β‐PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human β‐PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72–107 of the human β‐PPT polypeptide encode the sequence of neuropeptide K, an N‐terminally extended form of neurokinin A recently isolated from porcine brain.