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Effects of magnesium and sodium ions on the outer membrane permeability of cephalosporins in Escherichia coli
Author(s) -
Yamaguchi Akihito,
Yanai Misa,
Tomiyama Noribumi,
Sawai Tetsuo
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81528-9
Subject(s) - porin , escherichia coli , cephalosporin , permeation , chemistry , bacterial outer membrane , membrane , magnesium , biophysics , sodium , mutant , permeability (electromagnetism) , biochemistry , microbiology and biotechnology , biology , organic chemistry , gene , antibiotics
Both Mg 2+ and Na + stimulated the outer membrane permeation of negatively charged cephalosporins in Escherichia coli without any significant alteration of the permeation of a zwitterionic cephalosporin. Such stimulation was not observed in an E. coli mutant lacking porins. The stimulation was caused by the direct interaction between the cations and the porin pores, which resulted in a decrease in cation selectivity of both the Omp F and Omp C porin pores.