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The phage Mu repressor c and IS30 transposase proteins are significantly related
Author(s) -
Dalrymple Brian
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81520-4
Subject(s) - transposase , bacteriophage mu , insertion sequence , repressor , bacteriophage , biology , peptide sequence , dna , genetics , inverted repeat , homology (biology) , tn10 , direct repeat , amino acid , microbiology and biotechnology , gene , transposable element , escherichia coli , base sequence , genome , transcription factor
The IS30 transposase exhibits significant amino acid sequence homology to the phage Mu repressor c in the amino‐ and carboxy‐terminal regions of the proteins. The conserved sequences include the proposed Mu repressor DNA binding site, which is also related to the proposed Mu and D108 transposase DNA binding sites. The carboxy‐terminal homologies are characterised by two almost complete, and one partial, somewhat diverged amino acid sequence repeats. Only weak homologies to this domain are present in the Mu transposase (Mu A). Nevertheless, a clear link between an insertion sequence and a bacteriophage has been established.