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Donor and acceptor splice signals within an exon of the human fibronectin gene: a new type of differential splicing
Author(s) -
Vibe-Pedersen Karen,
Magnusson Staffan,
Baralle Francisco E.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81506-x
Subject(s) - exon , intron , rna splicing , gene , alternative splicing , exon trapping , splice , genetics , splice site mutation , biology , homology (biology) , exonic splicing enhancer , microbiology and biotechnology , rna
We have sequenced that area of a human fibronectin gene clone which codes for a connecting strand separating the last two areas of the type III homology. The gene has a complex exon with two ‘AG’ acceptor sites. One of these can be used (exon subdivision). In addition 93 basepairs inside the exon are sometimes spliced out as an intron. This is the third differential splicing found in the fibronectin gene transcript and it represents a new type of differential splicing.