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Effect of γ‐butyrolactone derivative on an artificial membrane
Author(s) -
Gräfe U.,
Schlegel R.,
Grigoriev P.A.,
Römer W.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81398-9
Subject(s) - derivative (finance) , chemistry , mutant , membrane , hydroxymethyl , flux (metallurgy) , stereochemistry , biochemistry , biophysics , biology , organic chemistry , gene , financial economics , economics
trans ‐2‐(6'Methylheptanol‐1'‐yl)‐3‐hydroxymethyl‐4‐butanolide(II) was shown to increase the passive flux of cations such as Co 2+ through a black lipid membrane made from ox brain phospholipids. This membranotropic effect appears to be involved in the activity of II towards blocked mutants of streptomycetes as an autoregulator of cytodifferentiation.