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Atrial natriuretic factor regulation of cyclic GMP levels and steroidogenesis in isolated fasciculata cells of rat adrenal cortex
Author(s) -
Jaiswal Neelam,
Paul Aranjiniyil K.,
Jaiswal Rama Kant,
Sharma Rameshwar K.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81236-4
Subject(s) - medicine , endocrinology , adrenal cortex , corticosterone , cyclic gmp , chemistry , second messenger system , cyclase , npr1 , biology , receptor , natriuretic peptide , nitric oxide , hormone , stimulation , heart failure
Isolated fasciculata cells of rat adrenal cortex, when incubated with atrial natriuretic factor (ANF), stimulated the levels of cyclic GMP and corticosterone production in a concentration‐dependent manner without a rise in the levels of cyclic AMP. The ANF‐dependent elevation of cyclic GMP was rapid, with a detectable increment in 30 s. ANF also stimulated the particulate guanylate cyclase. These results not only indicate the coupling of cyclic GMP and corticosterone production with ANF signal, but also demonstrate that, like the ACTH signal, cyclic AMP is not the mediator of ANF‐induced adrenocortical steroidogenesis.