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Fe‐dependent formation of a protein that makes mitochondria lipoxygenase‐susceptible during maturation of reticulocytes
Author(s) -
Rapoport S.,
Schmidt J.,
Prehn S.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81194-2
Subject(s) - mitochondrion , proteolysis , lipoxygenase , incubation , in vitro , reticulocyte , biochemistry , chemistry , biology , microbiology and biotechnology , enzyme , rna , gene
During in vitro incubation the mitochondria of immature reticulocytes fail to be degraded by lipoxygenase and subsequent ATP‐dependent proteolysis. Susceptibility is conferred on the mitochondria by a protein, the ‘mitochondria susceptibility factor’ which is synthesized during maturation of the reticulocytes in an iron‐containing medium.