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Interleukin 2 induces rapid phosphorylation of cellular proteins in murine T‐lymphocytes
Author(s) -
Kohno Michiaki,
Kuwata Shigeki,
Namba Yuziro,
Hanaoka Masao
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81179-6
Subject(s) - phosphorylation , microbiology and biotechnology , chemistry , biology
When quiescent murine T‐lymphocyte cells were stimulated by the addition of interleukin 2 (IL‐2), they reinitiated DNA synthesis after a lag period of 5 h. Under these conditions, rapid but transient phosphorylation of two cellular proteins with M r , values of 27000 and 26000 was detected; maximal phosphorylation occurred within 10–15 min after the addition of IL‐2. The protein of M r , 27 000 contained phosphoserine, while the protein of M r 26000 contained phosphothreonine.