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Identification of p26 xb and p24 xb of human T‐cell leukemia virus type II
Author(s) -
Shima Hiroshi,
Takano Masako,
Shimotohno Kunitada,
Miwa Masanao
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81129-2
Subject(s) - open reading frame , microbiology and biotechnology , chemistry , leukemia , antiserum , virology , peptide sequence , gene , biology , antigen , biochemistry , genetics
Human T‐cell leukemia virus type II (HTLV‐II) isolated from a T‐cell variant of hairy cell leukemia contains gag , pol and env genes as well as a fourth gene termed X , which can code three major open reading frames Xa, Xb and Xc. Proteins with molecular masses of 26 kDa (p26 xb ) and 24 kDa (p24 xb ) encoded by the Xb open reading frame were identified with antisera directed against synthetic peptides corresponding to the N‐terminal and C‐terminal amino acid sequences deduced from the structure of the Xb open reading frame. More than half the Xb products were found to be located in the nuclear fraction of HTLV‐II‐infected cells.