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Lipid peroxidation in regenerating rat liver
Author(s) -
Cheeseman K.H.,
Collins M.,
Maddix S.,
Milia A.,
Proudfoot K.,
Slater T.F.,
Burton G.W.,
Webb A.,
Ingold K.U.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81109-7
Subject(s) - lipid peroxidation , thymidine kinase , thymidine , microsome , liver regeneration , chemistry , biochemistry , dna synthesis , liver cell , antioxidant , endocrinology , medicine , dna , enzyme , regeneration (biology) , biology , immunology , microbiology and biotechnology , virus , herpes simplex virus
Rats entrained to a strictly regulated lighting and feeding schedule have been subjected to partial hepatectomy or a sham operation. In the partially hepatectomised animals the period of liver regeneration is characterised by regular bursts of thymidine kinase activity. Liver microsomes from rats, at times corresponding to maximum thymidine kinase activity, have much reduced rates of lipid peroxidation compared to control preparations: this is due in part to increased levels of lipid‐soluble antioxidant at times of maximal DNA synthesis. This temporal relationship between thymidine kinase and lipid peroxidation is consistent with the view that lipid peroxidation is decreased prior to cell division.