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Ethylene glycol causes acyl chain disordering in liquid‐crystalline, unsaturated phospholipid model membranes, as measured by 2 H NMR
Author(s) -
Nicolay Klaas,
Smaal Erik B.,
de Kruijff Ben
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81079-1
Subject(s) - ethylene glycol , phospholipid , chemistry , membrane , liposome , nmr spectra database , ethylene , oleic acid , proton nmr , nuclear magnetic resonance spectroscopy , crystallography , organic chemistry , spectral line , biochemistry , physics , astronomy , catalysis
2 H NMR has been used to probe the effects of ethylene glycol at the level of the acyl chains in liposomes prepared from dioleoylphosphatidic acid or dioleoylphosphatidylcholine, labeled with 2 H at the 11‐position of both oleic acid chains. Increasing concentrations of ethylene glycol lead to a proportional and substantial decrease in the quadrupolar splittings, measured from the 2 H NMR spectra of both liposomal systems, indicative of acyl chain disordering.