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Turnover of rat liver ornithine transcarbamylase
Author(s) -
Wallace Ruth,
Knecht Erwin,
Grisolía Santiago
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81062-6
Subject(s) - ornithine transcarbamylase , urea cycle , carbamoyl phosphate synthetase , ornithine carbamoyltransferase , urea , carbamyl phosphate , enzyme , biochemistry , mitochondrion , chemistry , ornithine , biology , amino acid , arginine
The relative half‐life of ornithine transcarbamylase from rat liver has been determined using the double isotope technique and affinity chromatography. The calculated half‐life (6–9 days) is similar to that of mitochondria and of the other mitochondrial enzyme of the urea cycle, carbamoyl‐phosphate synthase. Therefore, both mitochondrial urea cycle enzymes are most probably degraded mainly via the lysosomal (autophagic) pathway of mitochondrial protein degradation.