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Human inhibin genes
Author(s) -
Stewart Andrew G.,
Milborrow Helen M.,
Ring Jennifer M.,
Crowther Carol E.,
Forage Robert G.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)81006-7
Subject(s) - gene , biology , cloning (programming) , human genome , genetics , genome , conserved sequence , dna sequencing , southern blot , coding region , genomic dna , microbiology and biotechnology , peptide sequence , computer science , programming language
Inhibin is a gonadal hormone involved in the non‐steroidal regulation of follicle stimulating hormone (FSH) secretion. Using the cDNAs coding for bovine inhibin A and B subunits we have identified inhibin genes within the human genome using Southern blot hybridisation techniques. The genes are likely to be present as single copies. Cloning and sequencing inhibin genes obtained from lambda libraries of human genomic DNA provide structural and sequence data on the human A and B genes. Comparison of the known inhibin gene sequences showed, in particular, that the B subunits have identical sequences in man, pigs and cattle thus demonstrating a remarkable evolutionary conservation in these genes.