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Inositol phosphate production following α 1 ‐adrenergic, muscarinic or electrical stimulation in isolated rat heart
Author(s) -
Poggioli J.,
Sulpice J.C.,
Vassort G.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80999-1
Subject(s) - carbachol , muscarinic acetylcholine receptor , stimulation , inositol phosphate , medicine , inositol , endocrinology , phospholipase c , chemistry , contraction (grammar) , receptor , adrenergic , biology
A possible participation of polyphosphoinositide metabolism in the excitation‐contraction coupling in heart was investigated. Isolated rat ventricles prelabelled with myo ‐[2‐ 3 H]inositol were stimulated by conditions that increase mechanical activity. Both noradrenaline and carbachol increased the basal level of IP 3 IP 2 and IP by the activation of α 1 ‐adrenergic and muscarinic receptors, respectively. Electrical stimulation accelerated inositol lipid degradation by phospholipase C thus enhancing the IP 3 level as compared to quiescent ventricles. It is proposed that IP 3 may be involved in excitation‐contraction coupling in cardiac tissue.