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Protection of mice against Plasmodium berghei infection by a tuftsin derivative
Author(s) -
Gupta C.M.,
Puri Anju,
Jain Rakesh K.,
Bali Anu,
Anand Nitya
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80927-9
Subject(s) - plasmodium berghei , tuftsin , derivative (finance) , virology , plasmodium (life cycle) , biology , chemistry , immunology , malaria , biochemistry , parasite hosting , peptide , computer science , world wide web , economics , financial economics
In Plasmodium berghei infections, the mortality rate and parasitaemias were significantly reduced and the mean survival time was considerably enhanced by pretreating the animals with a tuftsin derivative, Thr‐Lys‐Pro‐Arg‐NH‐(CH 2 )2‐NHCOC 15 H 31 . This effect of the modified tuftsin was further increased upon its incorporation in the liposome bilayer. These results indicate that tuftsin and its derivatives may prove useful in enhancing nonspecific host resistance against protozoan infections.