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Characterization of the distribution of potential short restriction fragments in nucleic acid sequence databases
Author(s) -
Tung Chang-Shung,
Burks Christian
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80916-4
Subject(s) - genbank , nucleic acid , sequence (biology) , oligonucleotide , sequence database , biology , computational biology , database , genetics , dna , computer science , gene
We have searched the GenBank nucleic acid sequence database for potential short restriction fragments. All possible oligonucleotides up to length five are found at least once flanked by known restriction recognition patterns. Thus, searches in the database for a specific sequence corresponding to a desired oligonucleotide would often point to one or more sources of short, retrievable fragments containing that sequence. These results underscore the potential of nucleic acid sequence databases in planning experiments.