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The effects of phospholipase C on the voltage‐gated Ca current in Lymnaea stagnalis mollusc neurons
Author(s) -
Akopyan Abraham R.,
Chemeris Nikolai K.,
Iljin Victor I.,
Ilyasov Fuat E.,
Selishcheva Alevtina A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80909-7
Subject(s) - lymnaea stagnalis , phospholipase c , lymnaea , phospholipase , cytosol , phospholipase a2 , biophysics , phosphoinositide phospholipase c , microbiology and biotechnology , biology , neurotransmitter , chemistry , neuroscience , biochemistry , enzyme , signal transduction , snail , central nervous system , ecology
Application of phospholipase C to isolated voltage‐clamped molluscan neurons substantially increased the voltage‐gated Ca current ( I ca ) in most of the cells studied. In contrast, phosphoinositide‐specific phospholipase C inhibited I ca in all neurons. The mechanism of phospholipase C‐induced alterations of I ca is poorly understood at present, but they may have some relevance to plasma membrane phosphoinositide‐coupled changes in cytosolic Ca 2+ and to α‐adrenergic neurotransmitter control of neuronal I ca .