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Translational regulation of ornithine decarboxylase by polyamines
Author(s) -
Persson Lo,
Holm Ingvar,
Heby Olle
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80892-4
Subject(s) - ornithine decarboxylase , ornithine decarboxylase antizyme , chemistry , biochemistry , enzyme
The activity of ornithine decarboxylase (ODC), the first and rate‐limiting enzyme in the polyamine biosynthetic pathway, is dramatically increased in proliferating cells. In addition to transcriptional regulation of ODC, the present study shows that the enzyme is regulated at the translational level by putrescine and spermidine. ODC synthesis is inhibited by an increase and stimulated by a decrease in their cellular content. Spermidine is a more potent negative regulator than is putrescine. The effects of polyamines on ODC synthesis were not attributable to changes in the cellular content of ODC mRNA, thus demonstrating regulation at the translational level.