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Binding of gastrin to gastric transferrin
Author(s) -
Baldwin Graham S.,
Chandler Rosemary,
Weinstock Janet
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80883-3
Subject(s) - gastrin , transferrin , chemistry , medicine , biochemistry , secretion
Binding of 125 I‐gastrin 2,17 to porcine gastric transferrin has been demonstrated by covalent cross‐linking with disuccinimidyl suberate. The concentration of gastrin 17 required to reduce cross‐linking by 50% was approx. 100 μM. The occurrence of both gastrin and gastric transferrin in porcine gastric mucosa and lumen suggests a novel synergistic role for the observed interaction in the uptake of dietary iron.