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Calcium‐activated calcium permeability in parathyroid cells
Author(s) -
Gylfe Erik,
Larsson Rolf,
Johansson Hans,
Nygren Peter,
Rastad Jonas,
Wallfelt Chris,
Åkerström Göran
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80880-8
Subject(s) - calcium , extracellular , chemistry , biophysics , permeability (electromagnetism) , parathyroid chief cell , receptor , cytoplasm , biochemistry , parathyroid hormone , biology , membrane , organic chemistry
The Ca 2+ receptor mechanism of the parathyroid cell was studied using La 3+ as a probe. La 3+ was found to bind to the cell surface without further penetration. Measurements of 45 Ca fluxes and the cytoplasmic Ca 2+ concentration (Ca i 2+ ) revealed a stimulatory component in the action of La 3+ on Ca 2+ permeability resulting in a rise in Ca i 2+ These effects mimicked those obtained when raising the extracellular Ca 2+ concentration from 0.5 to 3.0 mM, but the actions of La 3+ and Ca 2+ were not additive. The results suggest the existence of a novel Ca 2+ permeability physiologically activated by binding of Ca 2+ to an external receptor.