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A new vitamin E analogue more active than α‐tocopherol in the rat curative myopathy bioassay
Author(s) -
Ingold K.U.,
Burton G.W.,
Foster D.O.,
Zuker M.,
Hughes L.,
Lacelle S.,
Lusztyk E.,
Slaby M.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80877-8
Subject(s) - bioassay , tocopherol , vitamin e , antioxidant , in vivo , vitamin , chemistry , biological activity , in vitro , myopathy , biochemistry , pharmacology , biology , medicine , genetics , microbiology and biotechnology
Vitamin E owes its biological effects to its antioxidant activity. Kinetic and mechanistic studies on phenolic antioxidants in vitro have led us to design and synthesize all‐rac ‐2,4,6,7‐tetramethyl‐2‐(4',8',12'‐trimethyltridecyl)‐5‐hydroxy‐3,4‐dihydrobenzofuran, 3. In the rat curative myopathy bioassay the acetate of this compound has 1.5–1.9 times the bioactivity of all‐rac‐ α‐tocopherol acetate. This represents the first time that a rationally designed synthetic ‘vitamin’ has been found to have more activity in vivo than the corresponding natural vitamin.