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1,25‐Dihydroxyvitamin D 3 enhances prostaglandin E 2 production by monocytes
Author(s) -
Koren R.,
Ravid A.,
Rotem C.,
Shohami E.,
Liberman U.A.,
Novogrodsky A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80876-6
Subject(s) - peripheral blood mononuclear cell , prostaglandin e , prostaglandin , monocyte , stimulation , prostaglandin e2 , chemistry , endocrinology , inhibitory postsynaptic potential , medicine , lymphocyte , mitogen activated protein kinase , microbiology and biotechnology , biology , biochemistry , in vitro
Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH) 2 D 3 on mitogen‐stimulated mononuclear cells. Addition of 1,25(OH) 2 D 3 (1nM) to mitogen‐stimulated mononuclear cells caused a 2–4‐fold increase in prostaglandin E 2 production during the second day of culture. The inhibitory effect of 1,25(OH) 2 D 3 on lymphocyte proliferation is greatly augmented up to 7‐fold in the presence of prostaglandin E 2 . We conclude that monocytes are involved in the inhibitory effect of 1,25(OH) 2 D 3 on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins.