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Inhibition by interferon (α + β) of mouse liver regeneration and its reversal by putrescine
Author(s) -
Nishiguchi Shuhei,
Otani Shuzo,
Matsui-Yuasa Isao,
Morisawa Seiji,
Monna Takeyuki,
Kuroki Tetsuo,
Kobayashi Kenzo,
Yamamoto Sukeo
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80866-3
Subject(s) - putrescine , dna synthesis , interferon , liver regeneration , stimulation , chemistry , dna , microbiology and biotechnology , biochemistry , intraperitoneal injection , biology , regeneration (biology) , pharmacology , endocrinology , immunology , enzyme
Mouse interferon (α + β) given to mice by intraperitoneal injection suppressed both the accumulation of putrescine and stimulation of DNA synthesis in liver caused by partial hepatectomy. The suppression of DNA synthesis was completely reversed by exogenous putrescine. The same results were obtained when core 2',5'‐oligoadenylate instead of interferon was given to partially hepatectomized mice. These results suggest that interferon inhibits putrescine formation through elevating the 2',5'‐oligoadenylate level and thus inhibits DNA synthesis in the regenerating liver.