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Activation of a D‐form of rabbit muscle glycogen synthase by Ca 2+ ‐activated protease
Author(s) -
Hiraga Akira,
Tsuiki Shigeru
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80853-5
Subject(s) - glycogen synthase , cytosol , chemistry , phosphorylation , biochemistry , proteolysis , phosphatase , gsk 3 , protein kinase a , protease , atp synthase , glycogen branching enzyme , enzyme , glycogen , gsk3b , enzyme activator , microbiology and biotechnology , biology
Glycogen synthase isolated from rabbit skeletal muscle as a D‐form (synthase D 2 ) is activated by a rat liver cytosolic protein differing from any of the known protein phosphatases (D 2 activase). Although reversible by phosphorylation by cyclic AMP‐dependent protein kinase, the activation is a result of limited proteolysis by D 2 activase, which has been identified as the Ca 2+ ‐activated protease.