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Exon structure of the collagen‐binding domain of human fibronectin
Author(s) -
Owens Raymond J.,
Baralle Francisco E.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80836-5
Subject(s) - fibronectin , exon , homology (biology) , gene , genetics , biology , fusion protein , microbiology and biotechnology , type iv collagen , extracellular matrix , recombinant dna , laminin
Fibronectin consists of a series of three internal homology repeats (types I, II, and III [(1983) Proc. Natl. Acad. Sci. USA 80, 137‐141]). The type III units are each coded for by two exons with the exception of the alternatively spliced extra domain type III [(1984) EMBO J. 3, 2511‐2516]. To investigate the gene organisation of the type I and II repeats, genomic clones covering the collagen‐binding domain of human fibronectin have been isolated and characterised. The results show that each of the type I and II homology units in this region corresponds to an exon. Taken together with the previous data concerning the type III units, the data lend support to a gene fusion model of fibronectin evolution.