Premium
A U3 RNA pseudogene in mouse: sequence and organization in genomic DNA
Author(s) -
Ferrer P.,
Qu L.H.,
Bouche G.,
Bachellerie J.P.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80834-1
Subject(s) - pseudogene , genetics , biology , rna , genome , sequence (biology) , dna , human genome , direct repeat , genomic organization , computational biology , gene
A mouse U3 RNA pseudogene has been identified; it corresponds to a U3B full length coding sequence with a 3'‐oligo(A) tail, precisely flanked at both ends by a pair of 15 bp direct repeats. These structural features suggest that it has arisen through an RNA‐mediated mechanism involving an insertion at staggered nicks in the genome. Sequence data indicate that this mouse specimen has been generated by a different event as compared to the recently described rat pseudogenes. It represents the first reported case, for a pseudogene of this class, to be present at more than one copy per genome.