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Cytotoxic effects of the lipophilic iron chelator omadine
Author(s) -
Kontoghiorghes George J.,
Piga Andrea,
Hoffbrand A.Victor
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80813-4
Subject(s) - cytotoxic t cell , chemistry , chelation , cytotoxicity , intracellular , incubation , pharmacology , in vitro , biochemistry , biology , organic chemistry
Cytotoxic effects were observed following 4 h incubation of human leukaemic cells with the iron chelator 1‐hydroxypyridine‐2‐thione (omadine). Its Cytotoxic activity was comparable to that of the cytotoxic drug doxorubicin. At the same concentration two other effective iron chelators, desferrioxamine and 1,2‐dimethyl‐3‐hydroxypyrid‐4‐one, were not cytotoxic. Addition of iron augmented the effect of omadine. It is suggested that the lipophilic properties of omadine and of its iron complex cause their intracellular accumulation and potent cytotoxic activity.