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The involvement of calcium in the stimulation of respiration in isolated rat hepatocytes by adrenergic agonists and glucagon
Author(s) -
Crompton Martin,
Goldstone Timothy P.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80811-0
Subject(s) - glucagon , isoprenaline , stimulation , phenylephrine , endocrinology , medicine , respiration , calcium , chemistry , cytosol , adrenergic , biology , receptor , hormone , biochemistry , enzyme , anatomy , blood pressure
The effects of adrenergic agonists and glucagon on respiration and cytosolic free Ca 2+ measured with quin2, in female rat hepatocytes have been compared. In the presence of lactate, all three agonists caused a permanent stimulation of respiration. However, unlike phenylephrine, glucagon induced only a transient increase in cytosolic free Ca 2+ and isoprenaline caused no detectable change. Mechanisms other than Ca 2+ for respiratory stimulation by cAMP‐linked agonists in liver are indicated.