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Identification of high levels of protein phosphatase‐1 in rat liver nuclei
Author(s) -
Kuret Jeff,
Bell Heather,
Cohen Philip
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80741-4
Subject(s) - phosphatase , protein phosphatase 1 , protein subunit , nucleus , microbiology and biotechnology , biochemistry , chemistry , protein phosphatase 2 , acid phosphatase , phosphorylation , phosphorylase kinase , protein kinase a , glycogen phosphorylase , cell nucleus , enzyme , biology , cytoplasm , gene
Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase‐1 in its molecular mass, sensitivity to inhibitor‐1 and inhibitor‐2 and specificity for the β‐subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase‐1 activity in nuclei is at least 5‐fold higher than its average extranuclear concentration.