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Localization of dolichols in phospholipid membranes
Author(s) -
Lai Ching-San,
Schutzbach John S.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80733-5
Subject(s) - phospholipid , membrane , chemistry , biophysics , biochemistry , microbiology and biotechnology , biology
We have used ESR methods employing spin‐labeled stearates to investigate the effects of dolichol on the motion of lipid molecules in phospholipid membranes of phosphatidylethanolamine and phosphatidylcholine. The ESR spectra show that the presence of dolichol affects the motion of the spin probes at carbon‐16, but not at carbon‐5. Similar results are obtained with phospholipid membranes comprising only phosphatidylcholine. It is suggested that dolichol molecules are present mainly in the lipid core region of phospholipid membranes.