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Phenolic antioxidants: potent inhibitors of the (Ca 2+ + Mg 2+ ‐ATPase of sarcoplasmic reticulum
Author(s) -
Sokolove Patricia M.,
Albuquerque E.X.,
Kauffman Frederick C.,
Spande Thomas F.,
Daly John W.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80726-8
Subject(s) - butylated hydroxytoluene , butylated hydroxyanisole , chemistry , endoplasmic reticulum , antioxidant , atpase , enzyme , organic chemistry , nuclear chemistry , biochemistry
Bis(2‐hydroxy‐3‐ tert ‐butyl‐5‐methylphenyl)methane (bis‐phenol) is the most potent inhibitor of the (Ca 2+ + Mg 2+ ‐ATPase of skeletal muscle sarcoplasmic reticulum yet identified. The compound behaves as a reversible, tight‐binding inhibitor with apparant K i = 0.3 μM. Butylated hydroxytoluene, butylated hydroxyanisole, and 4‐nonylphenol are also effective inhibitors. These observations are of particular interest in light of the widespread use of such phenolic antioxidants and stabilizers in the food industry and in the manufacture of rubbers and plastics and the ease with which the compounds are extracted into organic solvents.