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A polypeptide toxin from the coral Goniopora
Author(s) -
Qar Janti,
Schweitz Hugues,
Schmid Annie,
Lazdunski Michel
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80712-8
Subject(s) - toxin , activator (genetics) , contraction (grammar) , chemistry , marine toxin , stimulation , guinea pig , biophysics , biochemistry , microbiology and biotechnology , medicine , biology , endocrinology , receptor
A polypeptide toxin has been isolated from Goniopora coral with an M r of 19000. Goniopora toxin has the following properties: (i) it induces contraction of guinea pig ileum and this contraction is prevented by Ca 2+ ‐channel blockers; (ii) it stimulates 45 Ca 2+ influx in cardiac cells in culture and this stimulation is abolished by Ca 2+ ‐channel blockers; (iii) it prevents binding of (+)‐[ 3 H]PN 200‐110 to the Ca 2+ ‐channel protein of skeletal muscle T‐tubule membranes. All these results taken together suggest that Goniopora toxin is a Ca 2+ ‐channel activator.