Premium
Cytoskeletons of ADP‐ and thrombin‐stimulated blood platelets
Author(s) -
Pho D.B.,
Desbruyères E.,
Der Terrossian E.,
Olomucki A.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80660-3
Subject(s) - gelsolin , platelet , caldesmon , thrombin , chemistry , platelet aggregation , biochemistry , platelet activation , adenosine diphosphate , microbiology and biotechnology , actin , biophysics , enzyme , biology , immunology , calmodulin
Comparative analyses of the cytoskeletons of resting and stimulated platelets point out the involvement of a 79 kDa polypeptide in the activation step and its increased incorporation during aggregation. It appears as a doublet and cross‐reacts with an antibody to chicken gizzard caldesmon, whereas no 150 kDa immunoreactive form was detected. α‐Actinin and gelsolin were detected only in the aggregation step.