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A new hydrophobic anchor for the attachment of proteins to liposomal membranes
Author(s) -
Weissig V.,
Lasch J.,
Klibanov A.L.,
Torchilin V.P.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80654-8
Subject(s) - liposome , phosphatidylethanolamine , membrane , chemistry , covalent bond , chymotrypsin , phosphatidylcholine , yield (engineering) , biological membrane , biochemistry , enzyme , biophysics , trypsin , phospholipid , organic chemistry , materials science , biology , metallurgy
The model enzyme α‐chymotrypsin covalently modified by a phosphatidylethanolamine derivative has been attached to liposomal membranes in high yield. A maximal protein/lipid ratio of 5.4 × 10 −3 mol lipid was achieved.