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Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium
Author(s) -
Marc Sylvie,
Leiber Denis,
Harbon Simone
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80561-0
Subject(s) - inositol , myometrium , carbachol , oxytocin , phospholipase c , endocrinology , medicine , inositol phosphate , muscarinic acetylcholine receptor , guinea pig , inositol trisphosphate , chemistry , depolarization , extracellular , receptor , contraction (grammar) , biology , biochemistry , uterus
In the guinea pig myometrium prelabelled with myo ‐[2‐ 3 H]inositol, carbachol and oxytocin enhanced a concentration‐dependent and rapid release of IP 3 which preceded that of IP 2 and IP 1 . The specific receptor‐mediated phospholipase C activation degrading PIP 2 to IP 3 did not require the presence of extracellular Ca 2+ . The ionophore A23187 as well as K + depolarization failed to increase inositol phosphate accumulation. It is proposed that IP 3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.