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Solid‐phase peptide synthesis of human(Nle‐27)‐oxyntomodulin
Author(s) -
Audousset-Puech M.P.,
Dufour M.,
Kervran A.,
Jarrousse C.,
Castro B.,
Bataille D.,
Martinez J.
Publication year - 1986
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(86)80535-x
Subject(s) - peptide , chemistry , peptide synthesis , sequence (biology) , peptide hormone , peptide sequence , solid phase synthesis , biochemistry , hormone , gene
Oxyntomodulin is a peptide isolated from porcine intestine which consists of the whole glucagon sequence extended at its C‐terminal part by a basic octapeptide. The analogue (Nle‐27)‐oxyntomodulin of the human sequence has been synthesized by solid‐phase peptide synthesis, purified by HPLC and identified. Its biological activities are the same as those of the natural hormone.